Movement Disorders (revue)

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Persistent Sydenham's chorea

Identifieur interne : 004C76 ( Main/Exploration ); précédent : 004C75; suivant : 004C77

Persistent Sydenham's chorea

Auteurs : Francisco Cardoso [Brésil] ; Antonio Pedro Vargas [Brésil] ; Leonardo D. Oliveira [Brésil] ; Agostinho A. Guerra [Brésil] ; Selma V. Amaral [Brésil]

Source :

RBID : ISTEX:CAB92EE44ACBB2FE6D72A35DFCFF300C6FA5AC49

Descripteurs français

English descriptors

Abstract

BACKGROUND: Sydenham's chorea (SC) occurs in 26% of patients with rheumatic fever (RF). Despite usually being described as a self‐limited condition, few reports indicate that SC may persist in rare subjects. OBJECTIVE: To investigate the proportion of subjects with SC lasting more than 2 years and if clinical features differentiate patients with SC with a duration of less than 2 years (Group 1) from those with SC lasting more than 2 years (Group 2). METHODS: Prospective assessment of all patients with SC seen at our service from July 1993 through March 1998 analyzing the following: gender; age at onset; frequency of arthritis, carditis, family history of RF and SC; topographic distribution; and chorea severity on a 0–4 scale. RESULTS: Thirty‐two patients (19 female, 13 male) were studied. In Group 1 (16 subjects, 50%) the follow‐up period was 36.2 ± 20.0 months; 50% were female; age at onset was 10.9 ± 2.6 years; arthritis and carditis were present in 37.5% and 31.2%, respectively; family history of SC was reported by 18.7%; hemichorea was seen in 25.8% of subjects; and the mean intensity of chorea was 2.60.8. In Group 2, with a follow‐up period of 34.1 ± 18.9 months, 68.8% were female; age at onset was 9.3 ± 3.9 years; arthritis and carditis were diagnosed in 18.7% and 50%, respectively; no patient reported a family history of SC; hemichorea was observed in 6.2% of subjects; and the mean intensity of chorea was 2.8 ± 0.5. No difference was statistically significant. CONCLUSIONS: SC persists in half of our patients. Female gender, possibly related to endocrine factors, as well as the presence of carditis, indicating a more severe disease, may be risk factors for a longer duration of SC.

Url:
DOI: 10.1002/1531-8257(199909)14:5<805::AID-MDS1013>3.0.CO;2-P


Affiliations:


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Le document en format XML

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<div type="abstract" xml:lang="en">BACKGROUND: Sydenham's chorea (SC) occurs in 26% of patients with rheumatic fever (RF). Despite usually being described as a self‐limited condition, few reports indicate that SC may persist in rare subjects. OBJECTIVE: To investigate the proportion of subjects with SC lasting more than 2 years and if clinical features differentiate patients with SC with a duration of less than 2 years (Group 1) from those with SC lasting more than 2 years (Group 2). METHODS: Prospective assessment of all patients with SC seen at our service from July 1993 through March 1998 analyzing the following: gender; age at onset; frequency of arthritis, carditis, family history of RF and SC; topographic distribution; and chorea severity on a 0–4 scale. RESULTS: Thirty‐two patients (19 female, 13 male) were studied. In Group 1 (16 subjects, 50%) the follow‐up period was 36.2 ± 20.0 months; 50% were female; age at onset was 10.9 ± 2.6 years; arthritis and carditis were present in 37.5% and 31.2%, respectively; family history of SC was reported by 18.7%; hemichorea was seen in 25.8% of subjects; and the mean intensity of chorea was 2.60.8. In Group 2, with a follow‐up period of 34.1 ± 18.9 months, 68.8% were female; age at onset was 9.3 ± 3.9 years; arthritis and carditis were diagnosed in 18.7% and 50%, respectively; no patient reported a family history of SC; hemichorea was observed in 6.2% of subjects; and the mean intensity of chorea was 2.8 ± 0.5. No difference was statistically significant. CONCLUSIONS: SC persists in half of our patients. Female gender, possibly related to endocrine factors, as well as the presence of carditis, indicating a more severe disease, may be risk factors for a longer duration of SC.</div>
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